Pei lab is developing new genomics approaches and computational tools to understand cell fate and function of hematopoietic cells in development, aging and disease. By integrating immunology, neurobiology, stem cell biology, and state-of-the-art genomics approaches, we are working on the following topics:
(1) establish single-cell lineage tracing and spatial-omics technologies, dissecting the complexity of immune system in development and aging
(2) develop in vitro differentiation methods of hematopoietic stem cells for cellular therapy
(3) unravel physical cell-cell interactions at tumor-immune interface
(4) decode neuro-immune interactions in central nervous system disorders (such as brain tumor, neurodegenerative disease)
(5) build embryonic organ atlas and reveal embryonic cell heterogeneity using single-cell multiomics and machine learning